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KMID : 0882420080750060680
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Korean Journal of Medicine
2008 Volume.75 No. 6 p.680 ~ p.684
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A case of valproic acid-induced hyperammonemic encephalopathy
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Choi Jong-Hak
Kim Jung-Eun
Lee Kwang-Sun
Heo Chae
Nam Taek-Kyun
Kim Jeong-Wook
Park Seung-Won
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Abstract
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Valproic acid is an effective anticonvulsant used in neurology and psychiatry. Valproic acid-induced hyperammonemic encephalopathy is an unusual complication characterized by a decreasing level of consciousness, the development of progressive confusional states and, sometimes, a coexisting increase in the frequency of seizures after the onset of valproic acid treatment. It can lead to death, but can be reversed if a swift diagnosis is made. We report the case of a 58-year-old woman with an intracerebral hemorrhage and normal liver function who presented with valproic acid-induced hyperammonemic encephalopathy. After valproic acid treatment, she developed encephalopathy and became comatose, with seizures and a markedly elevated serum ammonia level. Her neurologic manifestations and hyperammonemia improved after discontinuing the valproic acid. (Korean J Med 75:680-684, 2008)
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KEYWORD
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Valproic acid, Hyperammonemia, Adverse effect, Seizure
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